Hello,

 
Welcome to the first edition of Healthy Joints for Better Living, a quarterly newsletter designed to provide helpful information and resources aimed at medical, health, fitness and other practitioners working with individuals concerned about their joint health. We hope you find this publication useful and we welcome you to share it with your clients, patients and colleagues.
Vol. 1 No. 1
 
Nutrition and Joint Health
By Jason Theodosakis, M.D.

A diet that includes a wide variety of foods in quantities that promote a healthy weight can help improve and maintain joint health.

Research shows that maintaining a healthy weight can help alleviate wear and tear on joints, and that weight loss can improve joint health for overweight or obese people. Excess weight increases the amount of stress placed on the joints, which can lead to impaired mobility and flexibility over time.

It is also well known that the types of foods in one's diet may affect joint health deterioration of healthy joints. Antioxidant-containing foods that include vitamins A, C and E as well as selenium are believed to promote joint comfort and provide numerous other health benefits.* Many different foods provide antioxidants, including most fruits and vegetables, oils from certain fish and seeds, and whole grains.

A second type of food that affects joints are certain oils. In particular, the omega-3 fatty acids found in coldwater fatty fish are believed to help limit flare-ups and boost the immune system.* The best sources of these fats are salmon, tuna, mackerel, anchovies, herring and sardines. It is recommended that meat or poultry be replaced with fatty fish meals at least twice a week. Nuts and seeds are also a good source of the healthier types of certain oils and should be included in the diet on a regular basis; however, they are high in calories so quantities should be kept small.

If it is not possible to obtain enough of the important nutrients from foods, taking dietary supplements, such as glucosamine and chondroitin, may be helpful. Exercise is also a vital component of a joint health regimen. Therefore, maintaining healthy joints will require attention to both diet and physical activity on an ongoing basis.

About Dr. Theodosakis: Jason Theodosakis, M.D. is an arthritis and sports medicine specialist and author of the New York Times best-selling book, The Arthritis Cure (St. Martin's Press, revised 2004).

Ask the Doctor

What are the best dietary supplements for promoting healthy joints?

There are dozens of supplements promoted for joint health. Glucosamine and chondroitin are by far and away the best researched and most widely used. Newer to the US compared to Europe, The European Authority for Rheumatology (EULAR) has classified these two supplements as category 1A (highest rating) for all interventions for both the level of evidence and strength of recommendation (see reference 1). Millions and millions of people worldwide have benefited from the daily use of these two dietary supplements. Recent clinical research shows that the combination of glucosamine and chondroitin yielded a synergistic effect in those of greatest need (see reference 2). Furthermore, compared to other interventions, the safety record of these two dietary supplements is unparalleled.

What's the best way to use glucosamine and chondroitin?

First of all, make sure the right amount is taken. Most of the research on the supplements involves the daily dose of 1,500 mg of glucosamine and 800 mg to 1200 mg of chondroitin. Taking these supplements all at once is preferred to splitting them up throughout the day, but it doesn't appear to matter if they are taken with or without food.

Second, the supplements should be used long-term. Unlike the use of some alternative preparations, the beneficial effects from glucosamine and chondroitin are enhanced by continued and long-term use.

Third, understand that changes in joint health are not necessarily indicative of how well the supplements are performing. In fact, even without noticeable changes, people are still able to reap the benefits of using glucosamine and chondroitin for the health of their joints.**

It helps some people to think of glucosamine and chondroitin for the joints in the same manner that they think of calcium and vitamin D for bone health.* The effects and benefits might take a while and may not even be obviously noticeable, but the long-term benefits are certainly well documented (see reference 3).*

Finally, ensure the quality of the product and that it is made in accordance with the guidelines set forth in the Good Manufacturing Practices (GMPs). Make sure to stick with a quality name brand product, preferably the leader in the category. This way you'll be assured that you're getting the greatest benefit for the health of your joints.

NIH GAIT Findings Debated at ACR 2006

"The Great Debate: Perspectives on Glucosamine and Chondroitin Sulfate" took place at The 70th Annual Meeting of the American College of Rheumatology (ACR) on November 14th in Washington D.C.

During this session, a panel of renowned joint health medical experts discussed last year's controversial findings of the National Institutes of Health (NIH) Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT), which, among other findings, concluded “combination glucosamine and chondroitin is effective in treating moderate to severe knee pain due to osteoarthritis (OA)" (see reference 4).

While those who conducted the study concluded that the overall test results did not indicate the efficacy of combination glucosamine and chondroitin, a pre-defined group encompassing patients with moderate to high pain showed 79.2 percent effectiveness (highly statistically significant) versus celecoxib (Celebrex) at 69.4 percent, which was not statistically significant versus placebo at 54.3 percent.

Jason Theodosakis, M.D., MS, MPH, a member of the steering committee for the $14 million NIH study, argued the position that the combination of glucosamine and chondroitin is effective in reducing pain and improving functional ability in patients with osteoarthritis. Dr. Theodosakis reviewed the totality of the evidence on glucosamine and chondroitin, two substances given the highest level of recommendation and strength of evidence by the European Union's main governing body in Rheumatology, EULAR.

Critics of glucosamine and chondroitin have pointed to the few studies that did not reveal a significant benefit compared to placebo. Dr. Theodosakis showed that these studies cannot provide evidence against the supplements due to several serious design flaws, including:

 
Insufficient duration of study
Insufficient or improper dosing of glucosamine
Uncontrolled use of active medications
Recruiting of subjects with mild pain to start
   
In the News: Glucosamine & Chondroitin

Over the last several months, the benefits of glucosamine and chondroitin have been making news. Referenced below are headlines from recent news articles and reports with links to the original sources.

The Real Truth About Remedies For Joint Pain
- Jean Carper Newsletter

Glucosamine and chondroitin for healthy joints
- Albany Times Union

A Joint-Healthy Recipe

The following recipe provides significant quantities of multiple beneficial nutrients including omega-3 fatty acids and antioxidants:

Lemon Salmon with Olives

Prep Time: 10 minutes
Total Time: 20 minutes
Serves: 4

Ingredients:
 
1 1/3 cup brown rice, uncooked
2 cups (16 oz) fat-free, low-sodium chicken stock
4 6-ounce pieces of raw salmon
2 lemons
12 stuffed green olives
1/2 teaspoon black pepper
48 fresh asparagus spears
8 cups mixed salad greens
2 whole tomatoes
8 tablespoons fat-free salad dressing, favorite flavor
8 teaspoons dry roasted, unsalted sunflower seeds

Preparation:

Preheat oven to 450°F. Prepare rice according to package directions, replacing 16 ounces of the water (2 cups) with chicken stock.

Meanwhile, place salmon on foil-lined baking sheet. Cut lemons into 1/3-inch slices; cut olives into 1/4-inch slices. Place lemon and olive slices over salmon. Sprinkle with freshly ground pepper to taste. Pull up the sides of the foil and add 8 Tbsp. water. Cover with foil, folding edges together, and seal edges securely. Cook salmon for 8 to 12 minutes or until fish flakes easily with fork.

While salmon is cooking, trim and steam asparagus spears in microwave or on stovetop until crisp-tender.

Serve salmon, rice and asparagus with a crisp salad. To prepare salad, wash and chop greens and tomato; toss with dressing and sunflower seeds.

Nutrition Information per Serving:
 
Calories: 620
Calories from Fat: 120
Total Fat: 14g
Saturated Fat: 3g
Cholesterol: 80mg
Sodium: 780mg
Total Carbohydrate: 77g
Dietary Fiber: 12g
Protein: 49g

Joint Health Tips
There are many things that can be done to help renew and maintain supportive cartilage surrounding joints and bones. A few tips below:
 
1.

Maintain a Healthy Body Weight.

  Research shows that every ten pounds of extra weight can increase joint stress by 1.4 times.
2.
Incorporate low-impact joint-strengthening exercises at least three times per week.
  Walking, biking and swimming are great ways to strengthen the joints and help protect the cartilage.*
3.
Use Joint-Supporting Dietary Supplements.
 

Vitamins A, C and E and the trace minerals selenium, manganese and boron are helpful for keeping joints healthy, while calcium is helpful for overall bone health.*

(The Arthritis Cure, St. Martin's Press, revised 2004)

Resources

The following resources provide valuable information on joint health and programs to promote joint care:

Arthritis Foundation (www.arthritisfoundation.com)

American College of Rheumatology (www.acr.org)

OsteoArthritis Research Society International (www.oarsi.org)

American College Sports Medicine (www.acsm.org)

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References:

1 -

Jordan K.M., Arden N.K. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann. Rheum. Dis. 2003;62:1145–1155

2 - Clegg D.O., Reda D.J., et. al. Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis. N. Eng. J. Med. Feb. 23, 2006 vol. 354 no. 8
3 - Beat A. Michel B.A., Stucki G, et. al. Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: A randomized, controlled trial. Arth. & Rheum. 2005; Vol. 52, Issue 3, pp: 779-786
4 - The Efficacy of Glucosamine and Chondroitin Sulfate in Patients with Painful Knee Osteoarthritis (OA): The Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) Abstract, October 2005

Source: Jason Theodosakis, M.D.